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KMID : 0363420080220010103
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Journal of Korean Oriental Pediatrics
2008 Volume.22 No. 1 p.103 ~ p.111
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The Comparative Study on the Difference of Anti-allergic Effects Based on Different Form of Seunggal-tang
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Kang Kyung-Hwa
Lee Hai-Woong
Yu Sun-Ae
Kim Hong-Bae
Lyu Ji-Hyo
Lee Seong-Yeun
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Abstract
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Objectives : Seunggal-tang is one of the prescriptions of oriental herbal medicine, which has been applied to several allergic diseases such as atopic dermatitis. This study was planned to compare differences of anti-allergic effects based on different form of Seunggal-tang by manufacturing differently.
Methods : Two types herb medicine products were used; aqueous extract (SG-T, Seunggal-Tang) and powder (SG-S, Seunggal-San) which were made from the same mixed formula of Seunggal-tang. To investigate in vitro anti-allergic activities, rat basophilic leukemia (RBL-2H3) cells were treated with SG-T and SG-S for 1 hour, and then stimulated with the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. We examined the release of beta-hexosaminidase, as a marker of degranulation, and the releases of tumor necrosis factor (TNF)-alpha and interleukin (IL)-4, as proinflammatory cytokines.
Results : SG-T and SG-S didn’t have effects on cell viabilities in concentrations under 2㎎/㎖. In additionto that, SG-T more inhibited releasing -hexosaminidase, TNF- and IL-4 than SG-S.
Conclusions : These results indicate that SG-T is more effective against mast cell-mediated allergic reactions than SG-S.
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KEYWORD
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Type were made from the same preparation, Seunggal-tang(SGT)
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